Are There Any Associations Among Coagulation Factor VII Gene Polymorphism, Plasma Activated Factor VII Levels, and Cerebrovascular Disease?

Are there any associations among coagulation factor VII gene polymorphism, plasma activated factor VII levels, and cerebrovascular disease?

Factor VII Gene Polymorphism, Plasma Activated Factor VII Levels, and Cerebrovascular Disease? To the Editor: We read with interest the article by Ghaddar et al1 showing no association of subclinical atherosclerosis with plasma coagulation factor VII (FVII) level or with FVII gene polymorphism (FVII R353Q), both of which were reported to be associated with myocardial infarction in whites.2,3 Th...

Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease: the Framingham Heart Study.

Elevated factor VII levels have been associated with increased cardiovascular risk in some studies. The arginine/glutamine (Arg/Gln) polymorphism of the factor VII gene has been previously shown to modify factor VII levels. However, the presence of a gene/environment interaction on factor VII levels or a link with cardiovascular disease (CVD) remains uncertain. We studied subjects from the Fram...

Preparation of factor VII concentrate using CNBr-activated

  Background: Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin-Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The a...

Factor VII assays, plasma triglyceride levels, and cardiovascular disease risk.

Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation.

Although the majority of factor VII (FVII) circulates in the zymogen form, low levels of activated factor VII (FVIIa) have been postulated to exist in plasma and to serve a priming function for triggering of the clotting cascade. However, direct measurement of plasma FVIIa has not previously been possible. We have quantified plasma FVIIa levels using a novel, highly sensitive assay that is free...